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1932

Pharmacology

Colorful illustration shows RNA molecules of various shapes.
Living World

The silent majority: RNAs that don’t make proteins

Once considered cellular junk, non-coding RNAs are emerging as key players in everything from brain development to cancer — with much still to be discovered

Illustration shows big blue blobs (proteins) to which are attached strings of colored shapes (sugar structures).
Living World

Sweet! The cell’s sugary coating comes into view

Built from thickets of glucose, galactose, mannose and more, the glycome plays key roles in cell communication, immunity and the blood-brain barrier

Collage of the back of a woman’s head, molecular structures, names of compounds in hair products, a flower and leaf.
Food & Environment

The science of green hair care

A push to move away from petroleum products — plus the perception that natural is gentler — has scientists lathering up new ingredients, from wood and fungus extracts to engineered proteins

A diagram shows a pancreas with a tumor within the larger digestive system.
Health & Disease

Progress fighting pancreatic cancer — one of the deadliest malignancies

Better outcomes may come from new drugs, strategies to rev up the immune system and learning to identify the disease sooner in its course

Digital illustration shows a yellow, crinkly cell with many red-orange particles emanating from it.
Health & Disease

Achieving lasting remission for HIV

People infected with HIV must take antiretroviral drugs for life. But promising trials using engineered antibodies suggest that ‘functional cures’ may be in reach.

Photo of a handsome stripy frog sitting upright on what looks like some moss.
Living World

Animals that eat poisons and don’t die

Critters consuming species that contain deadly toxins have evolved a suite of clever strategies to keep out of harm’s way

Photo, with shading, of a young woman holding an infant in her arms. She is leaning against the wall with a despairing look in her eyes.
The Mind

Postpartum depression: Better remedies, and now a predictive blood test

Scientists are learning more about this leading complication of childbirth. Treatments are improving and doctors can test for biological markers that flag heightened risk.

A colorized scanning electron microscope image of various pollen grains.
Technology

Using pollen to make paper, sponges and more

Reengineered, the powdery stuff could become a range of eco-friendly objects

Conceptual collage shows HIV virus, infected person, images of pills and microscope.
Health & Disease

HIV medications: Did fears about side effects come to pass?

The emergence of antiretroviral drugs saved millions of lives — but some worried about long-term health problems. Here’s how that turned out.

Conceptual image shows a prescription bottle containing worms.
Health & Disease

Worm-inspired treatments inch toward the clinic

Infection by certain wrigglers may reduce inflammation and fight obesity and diabetes. Scientists are at work to turn the findings into therapies.

A bristly, vivid green caterpillar sits on a piece of wood.
Living World

The caterpillars that can kill you

Some species make venoms that are deadly. With more research, those toxic compounds could yield useful medicines.

A conceptual collage shows a web of images such as false morels, the brain, neurons and a person in a wheelchair, against an image of mountains.
Health & Disease

A devastating nerve disease stalks a mountain village

Neurologists have grappled with a cluster of amyotrophic lateral sclerosis cases in France, where a fondness for a toxic wild mushroom may hold the answer

Photograph of a small child sitting in a waiting-room chair with fists covering their face.
Health & Disease

Severe irritability in children and teens: A new understanding

Kids with disruptive mood dysregulation disorder have explosive outbursts well past toddler age. Scientists are trying to work out the causes and what treatments help.

Silhouette of a person pinching their forehead in pain.
Health & Disease

Studies of migraine’s many triggers offer paths to new therapies

One class of drugs has already found success in treating the painful, disorienting and common attacks. Excitement is building about a slew of additional drug targets.

Conceptual illustration shows lab-coated scientists attempting to kick a field goal but missing by many yards.
Health & Disease

Why a diabetes drug fell short of anticancer hopes

Population and animal studies suggested it could treat cancer, but the clinical trials were a bust. Here’s what happened and what potential may remain.

Illustration of two kidneys, ureters and some major blood vessels, with some yellow blobs depicting a drug.
Health & Disease

Targeting the racial disparity in kidney disease

Some people of West African descent face a higher risk of renal failure. New drugs based on gene research may help right the ship — if they can reach everyone who needs them.

Collage with images of hospital, bacteria, viruses, patient and health-care worker.
Health & Disease

What if a virus could reverse antibiotic resistance?

In promising experiments, phage therapy forces bacteria into a no-win dilemma that lowers their defenses against drugs they’d evolved to withstand

Photograph of a warning label on the side of a cigarette pack. It says SURGEON GENERAL'S WARNING: Smoking Causes Lung Cancer, Heart Disease, Emphysema, And May Complicate Pregnancy.
Health & Disease

The tussle over cigarette warning labels, and the hazy future of vaping

Regulatory hurdles, industry objections and legal fights have gone on for decades over traditional tobacco. What’s in store for the next generation of smoking?

Conceptual illo shows a portion of a cell with receptors in its membrane. Little particles with radioactive symbols at their tips are floating around; one of them is docked onto the receptor.
Health & Disease

Radioactive drugs strike cancer with precision

The tumor-seeking radiopharmaceuticals are charting a new course in oncology, with promise for targeted treatments with fewer side effects

In a cartoon, an assortment of people — young and old, male and female — queue for a restroom, waiting to relieve their full-to-bursting bladders.
Health & Disease

To pee or not to pee? That is a question for the bladder — and the brain

How do we sense the need to urinate? The basic urge is surprisingly complex and can go awry as we age.

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