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How do body parts grow to their right sizes?

FIVE BIG QUESTIONS: Some cells seem to know what to do. Others apparently take their cues from outside. But really, “We don’t get it.”

Break on through: How some viruses infect the placenta

A few rare viruses can reach the fetus when pregnant women are infected, with tragic result. As explored in this Q&A, researchers are figuring out how the placenta acts as protector and how some pathogens slip through.

An amphibious rescue mission

On the edge of extinction, rare frogs and toads need more than a little love to reproduce. High-tech help, from IVF to hormone therapy, may save them.

Bent into shape: The rules of tree form

How do trees find their sense of direction as they grow? Researchers are getting to the root — and the branches — of how the grandest of plants develop.

The creative way to pay for wildlife recovery

OPINION: ‘Pragmatic rewilding’ restores damaged ecosystems and harnesses private money, with benefits for all

How do bodies map out left and right?

FIVE BIG QUESTIONS: Early in development, an embryo must “break symmetry” to position organs and other parts correctly.

How humans shift fish evolution | Things to Know

VIDEO: By targeting larger individuals, intense fishing may lead to a fishery dominated by the small

The puzzle of play

The purpose of play — for children, monkeys, rats or meerkats — has proved surprisingly hard to pin down. Scientists continue to toss around ideas.

Sounding out the brain

Ultrasound isn’t just for images. Sonogenetics and other promising technologies let researchers use focused sound waves to control genes and entire cells deep in the tissues of living animals, without surgery.

A master teller of fish stories

First came fugu. Then he took a bite out of sharks. Now a pioneer in genome research helps lead the effort to sequence every lineage of vertebrates.

Animal Weapons | Things to Know

VIDEO: How an evolutionary “arms race” leads to flashy horns, pincers and more across the animal kingdom

Mitochondria and the origin of eukaryotes

Were the powerhouse organelles a driving force or a late addition in the evolution of more complex cells like ours?

Why forgetting may make your mind more efficient

Evidence builds for ways that the brain actively erases memories

The accidental tree killers

Epidemics of forest-felling diseases are on the rise thanks to globetrotting pathogens that slip through even the best defenses. To prevent further losses, scientists are turning to high-tech surveillance and detection, even canine noses.

Hacking the immune system

How the body’s own defense cells can be turned into tiny, programmable assassins to battle cancers and other disorders

How plants turned predator

Carnivorous plants fascinate as much now as when their gruesome diet was first discovered. Molecular biology is helping botanists trace the origins of their predatory ways.

As coral die, protected areas aren’t enough

COMIC: The reef-builders face larger threats, scientists say. Chief among these is warming seas.

Prey tell: How moths elude bats

Millions of years of coevolution have given the insects a bag of tricks to escape their predators — from signal-jamming and decoys to acoustic camouflage

Labor of love

Flipping the scientific thinking on our species’ “difficult childbirth”

Cultural transmission makes animals flexible, but vulnerable

From monkeys washing potatoes to cockatoos raiding trash cans, socially spread behaviors allow creatures to adapt more rapidly to changing environments than conventional evolution would allow. But the traits are also more easily lost.

The monarch’s stupendous migration, dissected

COMIC: The feisty orange-black butterfly uses a toolbox of biological tricks to find its way down to Mexico for winter and flap north again in spring. Here’s how scientists figured out those tricks — and what they don’t yet understand.

The human hand in fish evolution

Fishery practices that go for the big ones may be counterproductive when mostly the small survive

A new history for the tropical forests of the Americas

Fossilized leaves and pollen are revealing the evolutionary past of New World tropical forests. The findings are helping to reshape predictions of what might happen to these ecosystems as the climate changes.

The truth in baby teeth

Fossilized remains of children have a lot to tell us about their short lives

How can ant and termite queens live so long?

Social insects disobey evolutionary principles that say creatures invest in body maintenance or reproduction — not both. Scientists want to know how the creatures do it.

How a poisonous plant became breakfast, lunch and dinner for monarchs

By engineering mutations into fruit flies, scientists reconstructed how the butterflies may have evolved resistance to the toxins found in milkweed, allowing their caterpillars to feast on the plant

Life in the soil was thought to be silent. What if it isn’t?

A handful of scientists have started to train their ears to the worms, grubs and roots underground. They were not prepared for what they heard.

At the dawn of life, did metabolism come first?

Some scientists propose that in the beginning, geochemistry gave way to biochemistry — with no genetic material necessary. Only later did RNA and DNA appear.

Five mysteries about breast milk

The little that we know about breastfeeding tells us a lot — imagine if we knew more

A Notch on the many paths to cancer

Tumors and more may be fueled by an ancient protein with myriad jobs in the body. Scientists hope to tap this knowledge to generate novel therapies.

The silence of the owls

No one knows exactly how the nocturnal hunters manage their whisper-soft flight, yet it is inspiring the design of quieter airplanes, fans and wind turbines

Why scientists need to be better at data visualization

The scientific literature is riddled with bad charts and graphs, leading to misunderstanding and worse. Avoiding design missteps can improve understanding of research.

Beat of life: Understanding the cell’s rhythms

VIDEO: Many cellular processes are guided by fluctuations of molecules, from circadian clocks to the feat of precisely dividing into two daughter cells

Making and breaking connections in the brain

The links between nerve cells, called synapses, allow us to learn and adapt, and hold clues to conditions such as autism, schizophrenia and more

How truffles took root around the world

For centuries, the wild delicacy grew only in Europe. But improved cultivation techniques have enabled the pricey, odorous fungus to be farmed in new landscapes.

A shocking number of birds are in trouble

Rich data on the global state of our feathered friends presents plenty of bad news — but also some bright spots. Researchers know better than ever how to help endangered birds, and there are notable bird conservation successes.

Could getting rid of old cells turn back the clock on aging?

Researchers are investigating medicines that selectively kill decrepit cells to promote healthy aging — but more work is needed before declaring them a fountain of youth

The mind of an anthill

Can we use the tools of psychology to understand how colonies of social insects make decisions?

Eyes on the deep

Decades of exploring the seafloor have helped oceanographer Samantha Joye tackle marine issues — from the underwater movement of oil from Deepwater Horizon to the biology of remote microbial communities

Betting on bats for genetic treasures

Bat genomes are full of clever tricks that are treats for biology and medical science — it’s why scientists want to sequence them all

Do wild animals get PTSD? Scientists probe its evolutionary roots

Many creatures show lasting changes in behavior and physiology after a traumatic experience

Searching for chocolate’s roots, and enemies, in Colombia’s wilderness

A newfound peace has spurred the hunt for disease-resistant wild cacao within the nation’s borders. What scientists find could help the country expand its role in the global trade.

How a giant eagle came to dominate ancient New Zealand

Before the formidable bird went extinct, scientists say, it likely hunted the islands’ flightless moa. Now evidence suggests the eagle was part of a wave of feathered invaders, and its story holds lessons for today and the future.

Marvelous misunderstood mistletoe

Best known as a holiday trimming, the parasitic plant is a botanical luminary in its own right. Research suggests it may give as much as it receives from the flora and fauna around it.

Total recall: A brilliant memory helps chickadees survive

In winter, the birds must remember where they’ve hidden tens of thousands of seeds. Biologist Vladimir Pravosudov explains what this can teach us about how the brain evolves.

Genetics extends the long arm of the law

In an evolving branch of forensic science, genealogists help solve crimes, sometimes identifying suspects with the DNA of distant relatives they’ve never met. As cold cases yield, concerns about privacy issues persist.

Sex strategies of the evolutionary kind

For women, a short-term fling may involve a quest for good genes or just a good time. It’s a puzzle for the researchers looking at how people choose mates.

How do bodies position arms, legs, wings and organs?

FIVE BIG QUESTIONS: Embryos use a ruler, of sorts, so they can create the right structures at the right spots from head to tail.

A salamander’s dangerous liaisons

The giant genomes of these struggling amphibians tell a story of outsider invasions, assault by disease and cross-species sex. A geneticist explains.

In praise of parasites

They worm into snails and infect the brains of fish. They’ve also found their way into Kevin Lafferty’s heart. He sees them as beautiful examples of sophisticated evolution, and as keys to ecosystem balance.

Seeking a better test for Alzheimer’s

New blood assays and brain scans are among the biomarkers revolutionizing clinical trials and changing the way researchers think of the disease. They may soon change the way patients are treated as well.

Tiny, living stones of the sea

How limestone-covered algae sway global climate — and how their fate may shift as the oceans acidify

Collective behavior: How animals work together

Studies of birds, fish and ants reveal the hidden ways groups coordinate movement, which might influence engineers designing drone armadas and efficient information flow

A long-overlooked brain region may be key to complex thought

The thalamus has traditionally been viewed just as the brain’s sensory relay station. But it may also play an important role in higher-level cognition, MIT’s Michael Halassa explains in a Q&A.

Marine wildlife is starting to suffocate

Global warming and agricultural runoff have driven the loss of oxygen in oceans around the world, with looming ecological consequences.

What do genes do? | Things to Know

VIDEO: Scientists have captured live video of parts of the most fundamental event in biology — cells reading and copying DNA instructions to make proteins

Dealing with rats, and their health, in America’s ‘rattiest’ city

OPINION: A study in Chicago found that rodents surviving poisoning are more likely to carry disease. Good pest control needs to take such things into account.

Color is in the eye, and brain, of the beholder

The way we see and describe hues varies widely for many reasons: from our individual eye structure, to how our brain processes images, to what language we speak, or even if we live near a body of water 

The curious case of the shrinking genome

Scientists are exploring why some creatures throw away bits of their DNA during development

Fun facts about bones: More than just scaffolding

A new vision of the skeleton as a dynamic organ that sends and receives messages suggests potential therapies for osteoporosis and other problems

Locusts and Grasshoppers | Things to Know

VIDEO: What’s the difference between these two insects? And what triggers a swarm?

Why you should care about parasites

VIDEO: Some hangers-on have a bad rep, but they're actually examples of sophisticated evolution

Humanizing immunology

The field has long been more mice than men. New technologies and systems-based approaches with human cells may soon fill gaps in our understanding of autoimmune disease and health, Mark Davis says in a Q&A.

The surprisingly tricky art of seed banking

To safeguard threatened plants, science must unravel the hidden biology of often-persnickety seeds as they age, sleep and awaken

Winding the body’s clock

Medicines and other small molecules may play a role in fixing rhythms gone awry

Cracking life’s code

We think we know DNA, but little progress has been made in understanding the evolution of how it encodes proteins

Growing a body, one tiny tug at a time

For decades, genetics and biochemistry have formed the bedrock of developmental biology. But it turns out that physical forces — the way cells push, pull and squeeze each other — play a huge role, too.

Earth to birds: Take the next left

Scientists have long thought that avian migration is guided by the magnetic field, but how, exactly?  The search has led to three very different hypotheses.

Structural biology: How proteins got their close-up

PODCAST: The journey to solving the structures of these critically important molecules began with a chance discovery. Today, after decades of painstaking lab work and huge technological leaps, the field of protein science is exploding. (Season 2/Episode 3)

The story of Snowball Earth

Ancient rocks suggest that ice entirely covered our planet on at least two occasions. This theory may help explain the rise of complex life that followed.

Getting to know the gut microbiome

Researchers are finally getting the tools to understand just how the microbial communities in and on our bodies affect health. But there are many mysteries left to solve — and many technological challenges.

Dung beetles: In the gutter, gazing at the stars

As they craft their humble lives from piles of manure, the insects look to the skies for direction

The essential fly

Think before you swat: The much-maligned fly could be the key to ensuring future supplies of many of the world’s favorite foods

Learning about birds from their genomes

Suddenly, biologists have hundreds of complete genome sequences of our feathered friends. That wealth of data is revolutionizing understanding of bird biology and evolution.

Heads up! The cardiovascular secrets of giraffes

Because of their height, giraffes require scarily high blood pressures — yet they escape the massive health problems that plague people with hypertension. Can clinicians learn from these animals?

Profiling the perpetrators of past plagues

The ancient pathogens in old graves are as dead as the people they once infected. Still, they tell a vivid tale.

Scientists can’t agree about Chernobyl’s impact on wildlife

Is Chernobyl a radioactive wasteland reeling from chronic radiation, or a post-nuclear paradise with thriving populations of animals and other life forms? Studies don’t always agree about levels of mutations and other ill effects.

Life’s a blur — but we don’t see it that way

Our brains manage to construct stable images even as our eyes keep darting around. Here’s what we know about how that happens. 

The history of climate change offers clues to Earth’s future

PODCAST: Digging — quite literally — into our planet’s past to study its paleoclimate has shed light on bygone ice ages and hints at trouble ahead for our now-warming world (Season 2/Episode 4)

The origin of mud

For most of Earth’s history, hardly any of the mucky stuff existed on land. It finally started piling up around 458 million years ago, changing life on the planet forever.

Darwin’s finches fall prey to a blood-sucking parasite

An invasive fly could mean the loss of bird species on the Galápagos Islands. To save them, scientists may introduce another invasive insect.

Why viruses deserve a better reputation

Sure they cause disease, but the microbes can be a help as well. Witness long-lasting pepper seeds, drought-resistant crop plants and even our own placentas.

Centuries of pondering — and squabbling about — trees

COMIC: Do forests warm or cool the Earth? What’s their effect on global climate change? A comic narrated by polymath Benjamin Franklin describes the evolution of thought on this issue and what we still don’t know.

Wild robots: Five ways scientists are using robotics to study animal behavior

Biomimetic bots can teach researchers a lot about how creatures interact in the natural world

The weird biology of asexual lizards

Some lizard species do without males altogether. Scientists are studying these all-female species to see what they might reveal about the pros and cons of sex.

As the Arctic warms, beavers move in

Scientists are just beginning to study the impacts of beaver dams on the tundra

Mixing it up in the web of life

Many types of marine plankton are either animal-like or plant-like. But a huge number are both, and they are upending ideas about ocean ecology.

The cultural lives of birds

VIDEO: Culture was once thought to be uniquely human, but scientists are finding evidence that many birds are also cultural creatures. What does avian culture look like? And why does it matter?

There goes the night

Artificial lights spell darker times for much of the planet’s wildlife — but it doesn’t have to be that way

As climate changes, so does life in the planet’s soils

To understand what might be lost, ecologist Janet K. Jansson taps molecular methods to explore Earth’s underground microbes, from the permafrost to the grasslands

As the Arctic warms, it’s losing more than just ice

SLIDESHOW: Also at risk are the many hidden habitats built into the sea’s frozen wilds.

Save the microbes!

OPINION: Recent data suggest that microbial diversity is under threat — which puts the entire planet at risk

The marks of extinction

The mass die-offs of Earth’s past may hold clues to our future

Animal personalities can trip up science, but there’s a solution

Individual behavior patterns may skew studies. A new approach called ‘STRANGE’ could help, by taking into account the habits, tendencies and life experiences of the creatures under scrutiny.

How lunar cycles guide the spawning of corals, worms and more

Many sea creatures release eggs and sperm into the water on just the right nights of the month. Researchers are starting to understand the biological rhythms that sync them to phases of the moon.

Bee gold: Honey as a superfood

From pesticide detox to increased longevity, the benefits of the sweet stuff go well beyond simply nourishing the hardworking insects in the hive

How animals follow their nose

It’s not easy to find the source of a swirling scent plume. Scientists are using experiments and simulations to uncover the varied strategies that animals employ.

How coral atolls get their gorgeous ring shapes

Sea levels rising and falling over hundreds of thousands of years helped build up these special islands

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