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Health & Disease

The silent majority: RNAs that don’t make proteins

Once considered cellular junk, non-coding RNAs are emerging as key players in everything from brain development to cancer — with much still to be discovered

Sweet! The cell’s sugary coating comes into view

Built from thickets of glucose, galactose, mannose and more, the glycome plays key roles in cell communication, immunity and the blood-brain barrier

What is wisdom, and can it be taught?

Scientists are trying to name the qualities that make someone wise and figure out how to cultivate them

The curious case of low-protein diets

In the lab, animals live longer on less of the stuff. How could this be, and what does it mean for human aging?

Looking for an ADHD coach? Choose carefully

As diagnoses surge, so does an unregulated coaching industry

Why disease outbreaks on Chinese fur farms are a serious risk to public health

Farming animals for fur is not only cruel but also provides an ideal environment for viruses to mix and cross over into humans

Beating back the Aedes aegypti mosquito

Scientists are taking a multipronged approach to tackle this dangerous carrier of dengue, yellow fever and other noxious viruses

Top science stories of 2025

In a year of funding chaos, ongoing climate change and pollution perils, we also saw the most powerful telescope yet, personalized gene therapy, and the next-best-thing to an HIV vaccine — not to mention a brand-new color

Progress fighting pancreatic cancer — one of the deadliest malignancies

Better outcomes may come from new drugs, strategies to rev up the immune system and learning to identify the disease sooner in its course

Journey to the egg: How sperm navigate the path to fertilization

COMIC: Male cells must survive twisty passages, strong currents and immune attacks; millions enter, but only one can finish

How plant-eaters snag their essential amino acids

Early in evolution, we animals lost the ability to manufacture nine of the 20 building blocks needed to make proteins. Herbivores evolved an impressive array of tricks to ensure their dietary needs are met.

Achieving lasting remission for HIV

People infected with HIV must take antiretroviral drugs for life. But promising trials using engineered antibodies suggest that ‘functional cures’ may be in reach.

Postpartum depression: Better remedies, and now a predictive blood test

Scientists are learning more about this leading complication of childbirth. Treatments are improving and doctors can test for biological markers that flag heightened risk.

Tracking down the hidden pollutants that make wildlife sick

A new technique for detecting unknown and unlooked-for chemicals is revealing dozens of contaminants in alligators, sea lions and condors

The pernicious infections infiltrating Ukraine’s front lines

Doctors and scientists are waging a shadow war in the besieged nation: bacteria that are resistant to multiple antibiotics. The deadly bugs are now knocking on western Europe’s door.

The clock is ticking: How epigenetics could help save wildlife from collapse

In polar bears, dolphins, baboons and more, molecular signatures of aging are changing how conservationists assess population health, resilience and risk

The other end of the weight spectrum: Very thin people

Researchers are exploring why some individuals are naturally super-lean and may struggle to gain weight. The causes of such constitutional thinness offer clues to the physiology of weight control.

Unsafe at home: The misery of intimate partner violence

Public health researchers explain the levers that can reduce — or worsen — this global blight. A bright spot: There are more data than ever on strategies that can help.

Mighty mitochondria: Cell powerhouses harnessed for healing

Infusion of the tiny, sausage-shaped structures helps to rejuvenate tissues deprived of blood. Researchers hope the technique can treat a variety of damaged organs.

Dogs and their people: Companions in cancer research

Canine and human cancers bear many similarities — studies in dogs are helping to develop treatments for both species

How rogue jumping genes can spur Alzheimer’s, ALS

Our genomes are peppered with DNA segments called retrotransposons that can move from place to place. When unleashed, some can kill nerves and promote inflammation — a discovery that may inspire treatments for neurodegeneration.

HIV medications: Did fears about side effects come to pass?

The emergence of antiretroviral drugs saved millions of lives — but some worried about long-term health problems. Here’s how that turned out.

Worm-inspired treatments inch toward the clinic

Infection by certain wrigglers may reduce inflammation and fight obesity and diabetes. Scientists are at work to turn the findings into therapies.

How climate change threatens eye health

Cataracts, pink eye and other ocular disorders are linked to heat, air pollution and higher UV exposure

Shared mobility: Making travel easier for all

Carshares, bikeshares and the like are a positive for the environment, though access to them isn’t equal. What can be done to give everyone more transportation options?

How stress shapes cancer’s course

Studies show psychological strain can accelerate tumors — could beta blockers slow them down?

Everything you need to know about bird flu

How dangerous is it? Where did it come from? H5N1 influenza’s origins stretch back to the 1990s, and key events paved the way for the outbreak we’re seeing today.

How cancer cells travel to new tissues and take hold

Understanding these astonishing migrations through the human body, known as metastases, could suggest novel treatments

Born in thin air: Overcoming the challenges of pregnancy at high elevation

In people not adapted to life at altitude, the sparse oxygen can impair fetal growth, causing problems that can last a lifetime. Researchers are searching for remedies.

Why sizzling cities are mapping hot spots street by street

In metros like Reno, Nevada, citizen scientists hit the road to collect detailed temperature data — key to taming urban heat, saving lives and designing for a warmer future

It began with a rabbit: Unraveling the mystery of memory

Half a century after the discovery of long-term potentiation, we’re still learning how the brain remembers

Pig organs in people: The future of cross-species transplants

Can genetically modified animals help ease the shortage of organs? After years of research into xenotransplantation, the field is at a turning point — yet risks and ethical issues remain.

Quiet couples: Alone time together

The right kind of silence can be golden, revitalizing and strengthening a relationship

Bringing the hospital into the home

A movement to provide hospital-level care for sick patients in their own beds, in the comfort of familiar surroundings, is growing in the United States — a trend already embraced in some other countries

We are all genetic mosaics

Picture your body: It’s a collection of cells carrying thousands of DNA errors accrued over a lifetime — many harmless, some bad, and at least a few that may be good for you.

A devastating nerve disease stalks a mountain village

Neurologists have grappled with a cluster of amyotrophic lateral sclerosis cases in France, where a fondness for a toxic wild mushroom may hold the answer

Top science stories of 2024

This record-setting year for heat saw stunning auroras, a map of a brain, a Dengue epidemic, the first look at rocks from the far side of the Moon, an AI energy scramble and more

The ones who need little sleep

Short sleepers cruise by on four to six hours a night and don’t seem to suffer ill effects. Turns out they’re genetically built to require less sleep than the rest of us.

The great green building makeover

Getting our homes and workplaces to be energy efficient has major benefits — but not when it is done one window at a time. Here’s why deep retrofits and biomaterials are key to more sustainable living.

Frogs kick back against lethal fungus

Scientists are seeing signs of resistance to the infections that have been wiping out the world’s amphibian populations — and developing strategies to aid in the fight Down Under

Severe irritability in children and teens: A new understanding

Kids with disruptive mood dysregulation disorder have explosive outbursts well past toddler age. Scientists are trying to work out the causes and what treatments help.

When ribosomes go rogue

Unusual variations in the cellular protein factory can skew development, help cancer spread and more. But ribosome variety may also play biological roles, scientists say.

The Cybathlon: Bionic athletes compete for the gold — and push assistive technologies forward

In the international competition, people with physical disabilities put state-of-the-art devices to the test as they race to complete the tasks of everyday life

Studies of migraine’s many triggers offer paths to new therapies

One class of drugs has already found success in treating the painful, disorienting and common attacks. Excitement is building about a slew of additional drug targets.

Why a diabetes drug fell short of anticancer hopes

Population and animal studies suggested it could treat cancer, but the clinical trials were a bust. Here’s what happened and what potential may remain.

Your cells are dying. All the time.

Some go gently into the night. Others die less prettily in freak accidents or deadly invasions, or after a showy display.

Targeting the racial disparity in kidney disease

Some people of West African descent face a higher risk of renal failure. New drugs based on gene research may help right the ship — if they can reach everyone who needs them.

What if a virus could reverse antibiotic resistance?

In promising experiments, phage therapy forces bacteria into a no-win dilemma that lowers their defenses against drugs they’d evolved to withstand

What’s that smell — and how’d you know?

It’s clear that genes, receptors and neurons all play a role in detecting odors. But much of how we make sense of what we sniff remains mysterious. A neuroscientist explains.

These proteins have been secretly managing your cells

Scientists have long known that histones spool DNA and help regulate genes. They may be doing a lot more.

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